Map - Frosinone, Italy Frosinone is a town and comune in Lazio, central Italy, the administrative seat of the Province of Frosinone.It is located about 75 kilometres south-east of Rome close to the Rome-Naples Autostrada A1. It is commonly identified as the capital of the geographical region of Ciociaria. Frosinone is on a hill overlooking the valley of the Sacco River, and is surrounded by the Ernici and Lepini mountain ranges.