Malarone (anti-malaria) drugs used by Capt. Greene in Afghanistan Malarone (atovaquone - proguanil) is a combination medication contains two active ingredients: atovaquone and proguanil. It is used to treat and prevent malaria. It works by killing P. falciparum, the parasite that causes malaria. It may be effective in areas where other antimalarial medications are no longer effective. Malarone 250 mg tablet Each pink, round, biconvex, film-coated tablet, branded "GX CM3", contains atovaquone 250 mg and proguanil HCl 100 mg (equivalent to proguanil base 87.4 mg). Nonmedicinal ingredients: low-substituted hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose, poloxamer 188, povidone K30, and sodium starch glycolate; coating: hypromellose, macrogol 400, polyethylene glycol 8000, red iron oxide, and titanium dioxide.